Principal Research Scientist within biophysical characterisation and pre-formulation

Would you like to make an impact on improving the quality of life of millions suffering from allergic diseases? Do you have flair for protein characterisation, an analytical and curious mindset and would like to be part of a drug discovery department in constant development?

The position
At ALK, we are dedicated to improving the quality of life for individuals suffering from allergic diseases. We are currently seeking a talented and experienced biophysical characterization and pre-formulation Scientist with expertise in drug discovery and biologics to join our team. The team is placed in the drug discovery department and is involved in early discovery and characterisation of new potential leads, such as allergens, antibodies and proteins. The team characterises lead candidates by applying several analytical methods covering both general protein-chemical methods and more specialized analytical tools like nDSF, HPLC, DLS, immunoassays and more. 

Your primary tasks will be:

• Apply protein characterisation methods to analyse protein structure, protein stability, protein aggregation or protein binding.
• Conduct thorough biophysical characterization of new potential drug discovery candidates.
• Expertly develop and optimize HPLC methods to analyze protein purity, impurity profile, and quantification for our biologic products.
• Design and develop immunoassays, including ELISA/Gyrolab, to precisely quantify target molecules and characterize immunological responses.
• Collaborate with cross-functional teams to drive research projects forward, fostering a comprehensive understanding of biologic products.
• Foster a creative and innovative environment by actively seeking new ideas and approaches in drug discovery and biophysical characterization.
• Actively participate in the scientific discussions across different projects, relevant international congresses, publish in international scientific journals and contribute to patents and innovations.

This is a lab-based position and in your everyday work life, you will be working closely with the scientists and technicians within the department. You are expected to work both independently and as a part of, multidisciplinary teams on several projects within Global Research.

Your profile
We expect that you have a Ph. D. in protein chemistry/biochemistry/medicinal chemistry/molecular biology or related fields and a minimum of 5 years of experience, preferably within the pharmaceutical industry. 

Furthermore, you:

• Have deep knowledge and experience within biophysical characterisation of protein stability and aggregation.
• Demonstrate exceptional experience and expertise in biophysical characterization and pre-formulation using techniques such as DLS, CD, nDSF and various HPLC methods.
• Exhibit strong problem-solving abilities, enabling you to address complex challenges in biophysical characterization, formulation, and stability design.
• Possess a strong sense of curiosity and a passion for drug discovery, continuously seeking to explore new ideas and concepts.
• Excellent oral and written communication skills; highly organized and efficient record keeping.
• Possess a collaborative mindset, effortlessly working with cross-functional teams to achieve collective goals.

Do you have experience with HPLC method development, Chromeleon software, immunoassay development (ELISA, MSD, Gyrolab) it will be an advantage.

Become a part of ALK
We provide an attractive working environment for individuals looking for both personal and professional development. ALK is a global pharmaceutical company specialised in allergy immunotherapy. We are driven by a high level of professionalism, integrity, an openminded approach and contributing to an inspiring and fun working environment together with our colleagues. You will be part of an engaged and informal team who values skill and knowledge creation. 

Our offices in Denmark offer a green view of the DTU Science Park in Hørsholm. We believe that physical presence enforces strong teamwork and collaboration and creates success, so it is important that you enjoy coming to work at our site with a degree of flexibility to also work from home.

Apply
Apply by attaching your CV and a short letter of motivation, no later than 21 July 2024. 

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants. Hence, we prefer that you do not add images in your application documents. We evaluate applications and call for interviews on an ongoing basis, so don't wait to apply! We reserve the right to take down the advert when we have found the right candidate.

Do you want to learn more about our company, we encourage you to visit us at www.alk.net. For further information regarding the position please contact Associate director, Helene Henmar +45 41 90 44 35.

We are looking forward to hearing from you!